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  • Adequate and well-controlled clinical studies have not been conducted in such patients to determine the optimal dosing regimen.
  • Strongyloidiasis in Immunocompromised Hosts In immunocompromised including HIV -infected patients being treated for intestinal strongyloidiasis, repeated courses of therapy may be required.
  • In addition, ivermectin does not readily cross the blood-brain barrier in humans.
  • In individuals who warrant treatment with ivermectin for any reason and have had significant exposure to Loa loa -endemic areas of West or Central Africa, pretreatment assessment for loiasis and careful post-treatment follow-up should be implemented.
  • Teratogenicity was characterized in the three species tested by cleft palate ; clubbed forepaws were additionally observed in rabbits.
  • Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals have not been performed to evaluate the carcinogenic potential of ivermectin.

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